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Aquilegia Downy Mildew vs Variegation

   
Variegated leaves Variegated leaves are a brighter yellow with green, there can be a few shades of green / yellow as can be seen on the right.

The amount of green vs the yellow varies from plant to plant.

Variegation in seedlings can be seen as soon as they germinate.
aquilegia-variegated-leaf
aquilegia variegated leaf
Sometimes it looks more like green variegation on a golden background, sometimes the other way around.

There may be tiny red edges to the leaves.
variegated-leaf-aquilegia
     
Downy Mildewed leaves This is about as strong a colour variegation as possible with downy mildew, usually it is much more subtle.

Look how the yellowy areas are angular, following the lines of the leaf veins (as DM is blocked from growing across the vein easily)downy mildew of aquilegia
downy mildew of aquilegia
Look how the yellowy areas are angular, following the lines of the leaf veins (as DM is blocked from growing across the vein easily)
Aquilegia downy mildew
Aquilegia-downy-mildew
     
Golden leaves Gold foliage on aquilegias is very beautiful. Again, it can be seen as soon as the seed germinates.
gold leaf aquilegia
aquilegia golden leaves
Downy Mildewdowny mildew aquilegia I do not think you will mistake the whiter-green leaves of systemically infected new aquilegia leaves with golden foliage, as it is not yellow. However, here are such infected leaves for comparison.

I have purposely selected rather 'burnt out' images that exaggerate the brightness of the fully infected leaves.

downy mildew aquilegia
     
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DOWNY MILDEW ON VARIEGATED LEAVES